• Nonivamide as a TRPV1 Agonist: Novel Insights for Cancer ...

  2025-09-23

  Explore the scientific advances enabled by Nonivamide, a capsaicin analog and TRPV1 receptor agonist, in cancer cell growth inhibition and inflammation modulation. This article examines emerging molecular mechanisms and translational applications relevant to oncology and neuroimmunology.

• Canagliflozin Hemihydrate in Advanced Glucose Homeostasis...

  2025-09-22

  Explore the research applications of Canagliflozin hemihydrate, a small molecule SGLT2 inhibitor, in the context of glucose metabolism and metabolic disorder studies. This article examines its mechanistic specificity and recent evidence that distinguishes it in molecular pathway research.

• ARCA EGFP mRNA: Advances in Direct-Detection Reporter mRN...

  2025-09-19

  Explore the applications and technical benefits of ARCA EGFP mRNA as a direct-detection reporter mRNA for fluorescence-based transfection assays and mammalian cell gene expression studies. Learn how co-transcriptional capping with ARCA and Cap 0 structure enhance mRNA stability and transfection efficiency.

• Advancing Mammalian Expression: EZ Cap Cy5 Firefly Lucife...

  2025-09-18

  Explore the unique advantages of EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP) for precise mRNA delivery and translation efficiency assays. This article highlights its Cap1 structure, Cy5 fluorescent labeling, and innate immune activation suppression in mammalian research applications.

• If the lack of specificity and the

  2025-04-22

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it Biotin-tyramide may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as

• Compound was docked into the active site of Aurora B

  2025-04-22

  

  Compound was docked into the active site of Aurora B kinase using Tripos sybyl-X ver. 2.1.1. The crystal structure of human Aurora B kinase cocrystallized with its potent inhibitor VX-680 was used for the docking analysis (PDB ID: ). The most likely binding conformations were selected based on the

• In many cells AR mediated activation of PLC has been

  2025-04-21

  

  In many Y-27632 dihydrochloride α1-AR mediated activation of PLC has been shown to be the downstream process for NA-induced signalling. The activated PLC initiates subsequent signalling by breakdown of PIP2 to IP3 and DAG (Fisher and Agranoff, 1987) and the process continues. To confirm if such mech

• Recent studies have indicated that V

  2025-04-19

  

  Recent studies have indicated that V-ATPase activity negatively regulates vacuolar fusion in vivo[17]. Since we have demonstrated that the pah1Δ Biotin-tyramide have a more acidic vacuolar pH than the WT cells, and the genes involved in the pump activity are upregulated compared to WT, the pah1Δ cel

• Our outcrossing data confirmed that ACL and

  2025-04-19

  

  Our outcrossing data confirmed that ACL1 and ACL2 have important temporal and spatial functions in ascospore delimitation in G. zeae. When each ACL deletion mutant was used as male for outcrossing, nuclear division and spore delimitation were not properly progressed in most asci. Ascospores that con

• br Crystal structure ACLY protein is a

  2025-04-19

  

  Crystal structure ACLY protein is a homotetramer of four identical subunits [9]. Each polypeptide chain contains 1101 amino-acid residues [10]. The crystal structure of full-length ACLY protein is yet unresolved. However, Sun et al. recently succeeded in crystallizing chymotrypsin-truncated human

• br Materials and methods br Results Dried

  2025-04-18

  

  Materials and methods Results Dried Y-27632 dihydrochloride used were 48.46 g C. benghalensis, 857.98 g T. zebrina and 25.09 g T. fluminensis. The samples gave 12.9% C. benghalensis, 0.078% T. zebrina and 3.06% T. fluminensis methanol extracts. The methanol extracts were evaluated for their l

• Several in vivo and in vitro studies have demonstrated

  2025-04-18

  

  Several in vivo and in vitro studies have demonstrated changes in bioactive lipid profiles under hyperglycemic conditions and have linked these changes with increased leukocyte adhesion and vascular dysfunction during diabetes. This input has originated partly from lipidomic studies that showed elev

• Firefly Luciferase mRNA (ARCA, 5-moUTP) br Perspective AA LA

  2025-04-18

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• Another contributor for the G M arrest in

  2025-04-17

  

  Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks 2X Taq PCR Master Mix (with dye) G2/M phase progression in various types of cancer cells (Kim et al., 2015, L

• Several studies have demonstrated that

  2025-04-17

  

  Several studies have demonstrated that depletion of functional ATR increases the sensitivity of cancer cells to oncogene-induced replication stress thereby hindering tumour growth and inducing extensive cell death (Gilad et al., 2010, Murga et al., 2011, Schoppy et al., 2012). Importantly, Schoppy e

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