• Acknowledgements This study was funded

  2019-09-09

  Acknowledgements This study was funded by Kuwait University Research Administration (Project MI03/10). Introduction Epidemiological, experimental and biologic plausibility support a cardioprotective effect of estrogens in women [1].

• The findings of Qiu et al. (2016) represent the first instan

  2019-09-07

  The findings of Qiu et al. (2016) represent the first instance of a Ub-specific mono-ADP-ribosyltransferase, as well as the first documentation of E1/E2 independent ubiquitination.

• Prostaglandin E receptor subtype 4 (EP4) is a

  2019-09-06

  Prostaglandin E receptor subtype 4 (EP4) is a transmembrane G-coupled protein receptor activated by prostaglandin E2 (PGE2).

• Information on the mechanism by which

  2019-09-05

  Information on the mechanism by which parasite infections promote ECM degradation is limited (McKerrow et al., 1983; Andrade, 1994; Lu and Lai, 2013; Thibeaux et al., 2014).

• While several C-terminal peptides have been

  2019-09-04

  While several C-terminal peptides have been reported to have modest (astressin) or substantial (astressin2-B, antisauvagine-30) subtype selectivity for the CRF2 receptor (), [125I]YP20 is the first reported small analog of the C-terminus of CRF exhibiting subtype selectivity for the CRF1 receptor vs.

• Yu et al also reported that extracting

  2019-09-03

  Yu et al. [24] also reported that extracting consortium of hydrolytic enzymes from sludge flocs performs better than costly single purified commercial enzyme.

• For LAU 399 extracted NF 340 chromatograms

  2019-09-02

  For LAU 399, extracted NF 340 chromatograms of the blank, t0, and t120 samples for the diagnostic product ion m/z 163.0216 are provided in Fig.

• Financial support NZ is an Established

  2019-08-30

  Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818643).

• Introduction Addiction to opioids such as

  2019-08-29

  Introduction Addiction to opioids such as morphine is a chronic disorder that affects the mesocorticolimbic dopaminergic pathway in the brain.

• A novel series of DHODH inhibitors was

  2019-08-28

  A novel series of DHODH inhibitors was developed by us based on a lead that was discovered during a docking procedure and medicinal chemistry exploration.

• Prenylation may turn a flavonoid from an agonist

  2019-08-27

  Prenylation may turn a flavonoid from an agonist to an antagonist and improve the selectivity to both ERs depending on the position of the substitution.

• P4H is a nonheme iron(II) dioxygenase that

  2019-08-26

  P4H is a nonheme iron(II) dioxygenase that uses O2 and α-ketoglutarate as co-substrates (Fig. 1A). The three-dimensional structure of mammalian P4H is unknown. We reasoned that an electrophilic analog of α-ketoglutarate could serve as an irreversible inhibitor of the enzyme and, hence, a useful probe for active-site residues.

• Oxidation of N-hydroxyguanidine 1 by DbH

  2019-08-24

  Oxidation of N-hydroxyguanidine 1 by DbH was studied by HPLC and some oxidation products for 1 could be characterized. The compounds generally observed with iron-containing systems are 4-methoxyphenylurea 11 and 4-methoxyphenylcyanamide 12 (Fig. 2).

• Discussion Human Chk a member of the

  2019-08-23

  Discussion Human Chk, a member of the Csk-family, was initially cloned from two different megakaryocytic cell lines [2], [3].

• In a study performed simultaneously by

  2019-08-22

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived Birinapant resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68].

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