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P4H is a nonheme iron(II) dioxygenase that
2019-08-26
P4H is a nonheme iron(II) dioxygenase that uses O2 and α-ketoglutarate as co-substrates (Fig. 1A). The three-dimensional structure of mammalian P4H is unknown. We reasoned that an electrophilic analog of α-ketoglutarate could serve as an irreversible inhibitor of the enzyme and, hence, a useful probe for active-site residues.
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Oxidation of N-hydroxyguanidine 1 by DbH
2019-08-24
Oxidation of N-hydroxyguanidine 1 by DbH was studied by HPLC and some oxidation products for 1 could be characterized. The compounds generally observed with iron-containing systems are 4-methoxyphenylurea 11 and 4-methoxyphenylcyanamide 12 (Fig. 2).
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Discussion Human Chk a member of the
2019-08-23
Discussion Human Chk, a member of the Csk-family, was initially cloned from two different megakaryocytic cell lines [2], [3].
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In a study performed simultaneously by
2019-08-22
In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived Birinapant resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68].
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In vitro studies in NSCLC cell lines expressing
2019-08-21
In vitro studies in NSCLC cell lines expressing EGFR mutants (T790M mutation, exon 19 deletion E746-A750, L858R/T790M double mutation), demonstrated that Rociletinib potently inhibits proliferation in the mutant EGFR NSCLC CX-4945 with Growth inhibition (GI50) values ranging from 7 to 32 nmol/L. In comparison, the GI50 value for wild type EGFR cells was 547 nmol/L.
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Chemokines act as ligands for the chemokine
2019-08-20
Chemokines act as ligands for the chemokine receptors, which possess 7-transmembran domain-type proteins functionally coupled to G proteins. Leukocytes express 19 chemokine receptors which control their influx and activation at the site of inflammation.
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CDKs as Direct Coactivators of Proinflammatory
2019-08-19
CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1.
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Conclusion Rational design of highly selective
2019-08-17
Conclusion Rational design of highly selective fluorescent probes to detect G-quadruplexes is of profound importance for basic research. On this basis, we designed and synthesized a series of N-alkylated styrylquinolinium dyes Ls-1, Ls-2 and Ls-3.
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Introduction Protein ubiquitination
2019-08-16
Introduction Protein ubiquitination is a posttranslational modification that plays a major role in almost all cellular processes in eukaryotes (Hochstrasser, 2009; Komander & Rape, 2012).
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Our study found a significant association
2019-08-15
Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P < 0.001).
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Discussion Although DNA has a limited chemical
2019-08-14
Discussion Although DNA has a limited chemical stability it has long been known that DNA in blood stains may remain relative stable for weeks, months, or even years at ambient temperature,1, 2, 3, 4, 5, 6 and samples (e.g., reference samples) that have been transferred to a matrix, e.g., FTA® paper, containing stabilizing agents are stable for at least 4 years.
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The HEV vaccine developed based
2019-08-13
The HEV vaccine, developed based on p239 particles, is of good efficacy, immunogenicity and safety, and was licensed in China in 2012.
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Hello world!
2018-07-29
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