• For LAU 399 extracted NF 340 chromatograms

  2019-09-02

  For LAU 399, extracted NF 340 chromatograms of the blank, t0, and t120 samples for the diagnostic product ion m/z 163.0216 are provided in Fig.

• Financial support NZ is an Established

  2019-08-30

  Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818643).

• Introduction Addiction to opioids such as

  2019-08-29

  Introduction Addiction to opioids such as morphine is a chronic disorder that affects the mesocorticolimbic dopaminergic pathway in the brain.

• A novel series of DHODH inhibitors was

  2019-08-28

  A novel series of DHODH inhibitors was developed by us based on a lead that was discovered during a docking procedure and medicinal chemistry exploration.

• Prenylation may turn a flavonoid from an agonist

  2019-08-27

  Prenylation may turn a flavonoid from an agonist to an antagonist and improve the selectivity to both ERs depending on the position of the substitution.

• P4H is a nonheme iron(II) dioxygenase that

  2019-08-26

  P4H is a nonheme iron(II) dioxygenase that uses O2 and α-ketoglutarate as co-substrates (Fig. 1A). The three-dimensional structure of mammalian P4H is unknown. We reasoned that an electrophilic analog of α-ketoglutarate could serve as an irreversible inhibitor of the enzyme and, hence, a useful probe for active-site residues.

• Oxidation of N-hydroxyguanidine 1 by DbH

  2019-08-24

  Oxidation of N-hydroxyguanidine 1 by DbH was studied by HPLC and some oxidation products for 1 could be characterized. The compounds generally observed with iron-containing systems are 4-methoxyphenylurea 11 and 4-methoxyphenylcyanamide 12 (Fig. 2).

• Discussion Human Chk a member of the

  2019-08-23

  Discussion Human Chk, a member of the Csk-family, was initially cloned from two different megakaryocytic cell lines [2], [3].

• In a study performed simultaneously by

  2019-08-22

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived Birinapant resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68].

• In vitro studies in NSCLC cell lines expressing

  2019-08-21

  In vitro studies in NSCLC cell lines expressing EGFR mutants (T790M mutation, exon 19 deletion E746-A750, L858R/T790M double mutation), demonstrated that Rociletinib potently inhibits proliferation in the mutant EGFR NSCLC CX-4945 with Growth inhibition (GI50) values ranging from 7 to 32 nmol/L. In comparison, the GI50 value for wild type EGFR cells was 547 nmol/L.

• Chemokines act as ligands for the chemokine

  2019-08-20

  Chemokines act as ligands for the chemokine receptors, which possess 7-transmembran domain-type proteins functionally coupled to G proteins. Leukocytes express 19 chemokine receptors which control their influx and activation at the site of inflammation.

• CDKs as Direct Coactivators of Proinflammatory

  2019-08-19

  CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1.

• Conclusion Rational design of highly selective

  2019-08-17

  Conclusion Rational design of highly selective fluorescent probes to detect G-quadruplexes is of profound importance for basic research. On this basis, we designed and synthesized a series of N-alkylated styrylquinolinium dyes Ls-1, Ls-2 and Ls-3.

• Introduction Protein ubiquitination

  2019-08-16

  Introduction Protein ubiquitination is a posttranslational modification that plays a major role in almost all cellular processes in eukaryotes (Hochstrasser, 2009; Komander & Rape, 2012).

• Our study found a significant association

  2019-08-15

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P < 0.001).

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