• Thus while there is ample evidence to rule out

  2021-10-09

  

  Thus, while there is ample evidence to rule out a generalized blockade of TGF-ß signaling by Hippo pathway activation upon establishment of cell–cell contacts, more recent studies have established that, in specific contexts, Hippo and TGF-ß signaling may either interfere or cooperate with each other

• br Activation of soluble guanylate cyclase The molecular ste

  2021-10-09

  

  Activation of soluble guanylate cyclase The molecular steps involved in sGC activation have evolved significantly over the last several years. The key studies are outlined below, but here we provide an overall summary. The activation mechanism of sGC was initially proposed to be relatively simple

• br Conclusion Interactions between neurons and

  2021-10-09

  

  Conclusion Interactions between neurons and astrocytes depend on the spatial configuration of their contacts. Therefore, changes of astrocyte morphology may impact various physiological mechanisms ranging from glutamate uptake and potassium homeostasis to modulation of synaptic transmission and p

• br Rho family GTPases are

  2021-10-09

  

  Rho-family GTPases are molecular switches; most which cycle from an ‘on’ GTP bound state to an ‘off’ GDP bound state, driven by GEFs (guanine nucleotide exchange factors) and GAPs (GTPase-activating proteins) respectively. Association with lipid membranes through a lipid (farnesyl or geranylgerany

• These and other observations presented in the elegant rigoro

  2021-10-09

  

  These and other observations presented in the elegant, rigorous study by Thomas et al. (2018) clarify a puzzling enigma regarding the Rab specificities of yeast TRAPP complexes and further highlight an important though under-appreciated role for the C-terminal HVD of Rabs in GEF substrate selection.

• On the basis of the structure

  2021-10-09

  

  On the basis of the structure of the Rab35/ACAP2 complex, the authors identified Thr76 in switch II of Rab35 as one key specificity determinant (Lin et al., 2019). The crystal structure shows that the hydroxyl group of Thr76 forms a praziquantel biltricide with Asp756 in ACAP2, while the methyl gro

• The hypothesis that genes involved in

  2021-10-09

  

  The hypothesis that genes involved in type 2 diabetes evolved under changing selective pressures and may carry the signature of natural selection motivated us to describe patterns of sequence variation at CAPN10 and GPR35 in human populations. An initial population genetics study reported an unusual

• In our studies the EC values for long

  2021-10-09

  

  In our studies, the EC50 values for long-chain unsaturated fatty acids added to the short form of human GPR120 receptor (BC101175), were higher than the EC50 values previously reported (Hirasawa et al., 2005) for the long form of GPR120 (NM_181745), which was co-expressed with Gα16 protein.(Table 2)

• Initial evidence that cell contact mediated transmission

  2021-10-09

  

  Initial evidence that cell-contact-mediated transmission of HIV-1 is relevant for the generation of latently infected SB269970 HCl was suggested in the context of transmission from dendritic cells to resting CD4+ T cells (Evans et al., 2013, Kumar et al., 2015). As dendritic cells probe for antigen

• br Conclusion The wild study reports

  2021-10-09

  

  Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and Atglistatin plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher novelty prefere

• Scriptaid The EEGs of these six patients interestingly

  2021-10-09

  

  The EEGs of these six patients interestingly showed focal, multi-focal and generalized spikes, which was an exclusion criteria in our study as we selected our cohort to exclusively represent focal epilepsy. Remarkably all of these cases were diagnosed with paroxysmal exercise-induced dyskinesia (PED

• Due to the requirement of high end

  2021-10-09

  

  Due to the requirement of high-end methods such as total internal reflection fluorescence (TIRF) microscopy to visualize lipid rafts, isolation procedures are employed to study the protein content of lipid rafts [29]. The different methods utilized to isolated lipid rafts and other low density micro

• br Material and methods br Results br Discussion

  2021-10-09

  

  Material and methods Results Discussion Functional characterization of naturally occurring GCK mutations in patients with impaired glucose homeostasis has widened our knowledge of the catalytic and regulatory mechanisms of this enzyme [3]. In this work, we have biochemically characterized a

• Beside these studies related to

  2021-10-08

  

  Beside these studies related to food, several groups examined the role of ghrelin in the actions of psychostimulants. Modulation of the ghrelin system and food restriction alter locomotor sensitization, DA release in the NAc, and CPP induced by cocaine, amphetamine, and nicotine (Abizaid et al., 201

• Platycodon grandiflorum is a member of the genus Platycodon

  2021-10-08

  

  Platycodon grandiflorum is a member of the genus Platycodon and is commonly known as balloon flower. In East Asia, P. grandiflorum is used for the treatment of asthma, coughs, inflammatory diseases, pulmonary tuberculosis, and diabetes (Takagi and Lee, 1972). Furthermore, recent studies have reporte

14322 records 552/955 page Previous Next First page 上5页 551552553554555 下5页 Last page