• 58 4 To date more than different mutations in the gene have

  2023-09-12

  

  To date, more than 50 different mutations in the gene have been described (Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff: SRD5A2 Gene: http://www.hgmd.cf.ac.uk). Most of them are missense mutations but premature stop codons and deletions leading to non-functional or su

• Acknowledgements The work was supported by grants from Swedi

  2023-09-12

  

  Acknowledgements The work was supported by grants from Swedish Research Council (J.Z.H.) (A.R.M.). We thank Protein Science Facility (PSF), Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. We thank Prof. Ralf Morgenstern (Department for Environmental Medic

• br Results br Discussion Our finding that AXL

  2023-09-12

  

  Results Discussion Our finding that AXL overexpression is significantly associated with poor survival in patients with high-grade serous OC is consistent with previous reports indicating that AXL regulates tumor growth in some cancers, as well as reports showing that AXL activity is involved i

• br Exocytosis of GLUT by autophagy br Conclusion br Conflict

  2023-09-12

  

  Exocytosis of GLUT4 by autophagy Conclusion Conflict of interest Ethics statement Antigen processing and presentation Adaptive immune response has to be instructed to identify and eliminate specific pathogens or foreign entities defined by their antigenic determinants. Processed antig

• br Regulation of V ATPase

  2023-09-12

  

  Regulation of V-ATPase assembly in response to changes in amino Cy5 TSA levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipid synthesis and autophagy.

• The elevated levels of intracellular

  2023-09-12

  

  The elevated levels of intracellular antioxidant such as reduced glutathione (GSH) are normally oberserved is various tumor Dp44mT synthesis which confers the chemoresistant to chemotherapy [59]. Therefore, the induction of oxidative stress via elevation of intracellular ROS and dimunition of intrac

• The mitochondrial protein AIF was the first caspase

  2023-09-12

  

  The mitochondrial protein AIF was the first caspase-independent death effector. AIF can induce caspase-independent chromatin condensation and large-scale DNA fragmentation to approximately 50 KB. AIF that is released to cytoplasm can mediate apoptosis when special extracellular signals trigger the o

• Furthermore because most of foods and beverages

  2023-09-12

  

  Furthermore, because most of foods and beverages have been consumed after processing, researchers have focused on the effects of processing (e.g. blanching, cooking, drying, cooling, freezing, high-pressure treatment, pulsed electric field) on total antioxidant capacity of foods. In general, there w

• br Introduction Heart Failure HF is a major and growing

  2023-09-11

  

  Introduction Heart Failure (HF) is a major and growing health challenge in India and the developing countries. It is one of the most important causes of morbidity and mortality in the industrialized world. The incidence and prevalence estimates of HF are unreliable in India because of the lack of

• Based on the general structure function principle in biology

  2023-09-11

  

  Based on the general structure-function principle in biology [[19], [20], [21]], toxic oligomers are expected to have well-defined three-dimensional structures to carry out their pathological functions. A common amyloid toxicity mechanism also suggests that toxic oligomers of different amyloid prote

• Structural and functional imaging studies searching for spec

  2023-09-11

  

  Structural and functional imaging studies searching for specific cortical areas related to each cognitive function domain have provided clues to the spreading patterns of cognitive dysfunction (Domoto-Reilly et al., 2012, Firbank et al., 2016, Li et al., 2012, Machulda et al., 2003, Mandal et al., 2

• The functional significance of the cap residues

  2023-09-11

  

  The functional significance of the cap residues with regard to the established role of PfA-M1 in hemoglobin catabolism in the food vacuole is a key question that is difficult to address with in vitro studies. We note that three of the dipeptide substrates used in our study are found in the sequences

• Em um estudo com modelos de ratinhos triplamente

  2023-09-11

  

  Em 2011, um estudo com modelos de ratinhos triplamente mutados para autotaxin inhibitor doença de Alzheimer expôs um grupo a anestesia geral com halotano ou isoflurano cinco horas por semana durante quatro semanas (a três diferentes idades: dois, quatro e seis meses) e um grupo sem exposição aos ane

• The present study determined the effect

  2023-09-11

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that RG2833 australia non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascular c

• Aberrant or a sustained activation of

  2023-09-11

  

  Aberrant or a sustained activation of AhR signaling pathway, triggered by exogenous toxic ligands such as dioxins, PAHs or polychlorinated biphenyls (PCBs), is a well-described biological process engaged during tumor initiation and/or promotion in various tissues (e.g. liver, lung, skin)(reviewed in

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